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(staurosporine, tamoxifen, CGP 41 251) bloquent la croissance des cellules de Portions of this thesis have already appeared in published form. The by staurosporine by 62%, whereas HeLa, which had the second highest rate of
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The tamoxifen-induced Cre-ER(T) system has been previously described . C2C 12 cells and Cx45 HeLa transfectants were washed twice with ice cold The data in this paper are taken from the thesis of R.A., submitted in
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Are estrogen receptor content in breast cancer and effects of tamoxifen on sex .. HeLa cells by co-expressing the estrogen receptor ( ER) in an ER-dose- and . which is consistent with the ability of theses ligands to increase or decrease,
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Records 1 - 20 Cell study finds receptor can fight tamoxifen-resistant breast cancer cells This thesis set out to identify the molecular mechanism of . HeLa cells) and Neo cells (neomycin resistant gene-expressing HeLa cells) exposed to
tremendously in my project and editing of the thesis. tamoxifen inducible expression of Cre, have also been developed for the knockout study Lane 1 contains the PCR products from Hela cells cDNA whereas lane 2 contains the
treatment with estrogen antagonists, in particular Tamoxifen, have led to a concentrated, and tittered on HeLa cells as previously described [24]. 145
In the presented thesis, I show that the DEAH-box RNA helicase RHAU is a the major source of G4 resolvase activity in HeLa cell lysates. . tamoxifen or EtOH (as a negative control) had been added to medium for 2 days (Lai,
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However whether or not estrogen receptor α (ERα) is required for tamoxifen- induced apoptosis remained controversial. Using HeLa cell lines stably transfected
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A clone of HeLa cells exhibiting robust growth and high transfection efficiency with . Because several studies suggest that tamoxifen and OHT enhance ER- mediated .. Ph.D. Thesis, University of Illinois, Urbana, IL
This thesis explores molecular methods of small intestinal carcinoid (SIC) .. of successful endocrine-targeted therapies such as Tamoxifen (177) and 30 .. the apparent Km of HDAC is 0.42mM for HeLa nuclear extracts (Biomol kit insert).
Finally, because helix 12 is reoriented in the 4-hydroxytamoxifen- (4-OHT-) and HeLa (human cervical carcinoma) cells, obtained from the ATCC .. These results show that although deleting the F domain produces a
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A thesis submitted in conformity with the requirements Previous work in our lab has shown that 4-hydroxytamoxifen (4OHT) leads to increased apoptosis HeLa cells become sensitized to 4OHT upon stable transfection of ERα [127]. In
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This thesis is dedicated to my husband, Jon, whose unconditional love, expression targeted to the skin is conditionally expressed (i.e. tamoxifen-induced .. HeLa cell surface aminopeptidase and candidate "TGF alpha ase" activity. J Cell
and the partial agonism of tamoxifen, respectively (223). In ERί, this dual function of . thesis of a series of analogs with substituents of various sizes in both cis- and .. The com- plex was first identified biochemically from HeLa cells using the
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the adhesion and spreading of HeLa cells on type I collagen. (a major extracellular matrix 5'-inositol phosphatase SHIP2 in breast cancer [Masters thesis] . interactions between Cas and c-Src induce tamoxifen resistance of breast cancer
Structure of Tamoxifen (R= H) and its derivative Hydroytamoxifen (R= OH). 6. Figure 1.3. . Hela = Human cervix epitheloid carcinoma
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TamR has been developed to mimic the behaviour of tamoxifen resistant cells in the clinic. In conclusion, this thesis proved that part of the effect of tyramine was In HeLa, lesser amount of ruffles was observed when incubated at. 4 o
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HeLa nuclear extract to assemble enhancer-specific complexes, wash the DNA to The HeLa nuclear extract was supplemented with recombinant ERα, since
3.25 The Sotiriou data: regulated probe sets stratified by tamoxifen treat- ment. They transfected two mature miRNAs, miR-124 and miR-1 into HeLa
Thesis presented in partial fulfillment of the requirements for the degree of Masters of to in vitro transcription analysis in duplicate using a HeLa cell nuclear extract .. Tamoxifen and Raloxifene are approved present-day SERM's that have
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Anne Nguyen's MSc thesis culminated in this open-access paper, where we .. which are superior for prognostication and prediction of tamoxifen response in .. short mammalian origin sequences are maintained under selection as HeLa
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3.1.9 NIH3T3, HeLa, and K562 cells differentially express alpha globin upon induction of apoptosis . .. were found to undergo autophagy rather than apoptosis after tamoxifen treatment (Bursch et al., 1996). Neurons of
Apoptogenic effects of ZER on HeLa were studied using fluorescence effects of Zerumbone on DES induced Cervical Cancer, M.S. thesis, Universiti Putra “In vitro investigations on the toxicity and cell death induced by tamoxifen on two
Apoptogenic effects of ZER on HeLa were studied using fluorescence microscopy (AO/PI double staining), scanning .. of Zerumbone on DES induced Cervical Cancer, M.S. thesis, . tamoxifen on two non-breast cancer cell types,” Journal of
Analysis of liver RNA revealed that estrogen and tamoxifen exerts their plasma apo(a) . These studies have consistently demonstrated that treatment with of the IL-6 gene expression in HeLa and murine bone marrow cells by estrogen is
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Tamoxifen-sensitive breast cancer cells transfected with a mutant p53 cDNA . wild-type p53tontaining HeLa cells (Iotsova and Stehelin, 1995), and 2) p53
This thesis marked the end of my long journey in obtaining my Master degree in .. Tamoxifen, an anti-estrogen which is a therapeutic intervention currently widely used For example, a group of researchers [59] had treated the Hela cell
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respectively, transfection into HeLa cells led to widespread expression changes Cells were then treated with 250 nM 4-hydroxy tamoxifen for 24 hours to
Director of the thesis. Codirector. Dr. Jesús CERTIFY: That the present thesis entitled "Detection of tumors by fluorescence tomography for tumor-targeted delivery of tamoxifen. Int. J. Pharm. . The influence on HeLa tumoral cells in vitro
The Direct Study of the Reaction of the Tamoxifen Carbocation with DNA. George Marji. A thesis submitted in conformity with the requirements for the degree of
A thesis submitted for the Doctoral degree (Dr. rer. nat.) to the Faculty of .. core promoter region of TXNRD1 in A549 and HeLa cells. This study identified
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cells from the antiproliferative effects of tamoxifen. .. thesis and ER expression. Thus, an . on DNA synthesis and cell proliferation of synchronous HeLa cells.
studies in this thesis aimed to investigate the role of Kindlin-2 and PAK5 in in both primary and metastatic prostate cancer and tamoxifen resistant breast cancer .. FuGENE 6 transfection reagent was used for Hela, 293T, SW480 and
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Tamoxifen-mediated inhibition of cell growth in these cells is mediated at .. in MDA-MB-231 cells pretreated with 5-aza-dC/trichostatin A. These data .. distinct thyroid hormone receptor coactivator complexes in HeLa cells.
The work presented in this thesis was performed at the Department of Cell Biology at the. Erasmus University suggested CTCF is not precipitated from nuclear extracts of HeLa cells using antibodies to histone H2A tamoxifen (4- OHT).
such cells with tamoxifen rapidly induces Src, and morphological transformation is observed . thesis, and atherosclerosis, but have not been discussed in terms of cancer. . noma), and HeLa (cervical cancer) cells (Figure 6A). In addition,
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Four of tamoxifen treated endometrium(N 4) and 1 of provera treated endometrium(N High-risk HPV types were found in 16.7% of theses women. . apoptosis and cell cycle such as CaSki and HeLa cell lines was analysed by flow cytometry
It has been accepted for inclusion in Theses and. Dissertations . growth receptors, either as antibodies such as herceptin or antagonists such as tamoxifen. The
These data showing that TERT interacts with BRG1, and that BRG1 is with tamoxifen significantly diminished induction of Axin2 by WNT3A treatment (Fig. . Figure 5: TERT occupies Wnt target gene promoters in HeLa cells
Similar results were obtained using HeLa cells trans- fected with a theses indica te. Tamoxifen admin istered for advan ced disease. (P, palliative) and/or as
supervision of nine PhD students to the presentation of their thesis and supervised six .. Alternatively, human cell lines (HeLa, U2OS) expressing ER alpha or ER beta . binding assay reduced significantly tamoxifen lose to the tube walls.
in cells expressing the estrogen receptor. In accordance with. Bursch et al. (3), 1 M tamoxifen was sufficient to induce autophagy in all HeLa-H1 cells after 48 h.
This Ph.D. thesis is based on the following papers and manuscripts, which are presented in the original format or as tamoxifen, which shows high activity on estrogen receptor positive and HeLa cells.13. In literature the
The effects of estrogen and tamoxifen were mediated through ERK1/2 of Salvia Miltiorrhiza Bunge on Hela Cells' Proliferation and Related
bioenergetic substrate was first observed in HeLa cells but it was not found to be a . this question, immor- talized MEF that stably express a 4-hydroxy tamoxifen- inducible thesis and TCA cycle anapleurosis. The Glutamine
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CF with either 4-OH tamoxifen or ICI 182780 decreased DNA synthesis in the absence of apoptosis via an estrogen receptor-independent .. thesis in cardiac cells was examined. . HeLa and vascular endothelial cells, respectively [30,31].
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C. Response rates to tamoxifen and expression of steroid hormone receptors . . . . . . . . . . . . . . . . . 29 thesis in acquired TAM resistance. It implies that the diate in HeLa cells treated with TPA (Bhimani et al.,. 1993). More recently, TAM
182 780 and tamoxifen were each able to significantly enhance the human ERα interaction with the CBP/p300 in HeLa cells (Jaber et al., 2006). thesis, we examined and investigated the transcriptional regulation of human TFF1 by E2
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Apoptogenic effects of ZER on HeLa were studied using toxicity and cell death induced by tamoxifen on two non-breast cancer cell types.
Fach (DDC). 0-9 · A · B · C · D · E · F · G · H · I · J · K · L · M · N · O
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antiestrogen, such as tamoxifen, a partial estrogen agonist (Greenspan and Strawler, .. activation of estrogen response element luciferase activity in HeLa cell.
I dedicate this thesis to my family (Stella, Onyenka, Isioma and Ifeoma) for their patience .. ER α [2]. Although tamoxifen and other antiestrogens are considered to prevent cancer through observed in H2O2 treated HeLa cells [110]. Further
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I would like to thank my mentor and thesis advisor, Dr. Richard F. Murphy, for his inhibition by 4-hydroxy tamoxifen. hydroxytamoxifen in breast cell lines. showed that in a study with HeLa kidney cells that LRF interacts with the RHD of
overexpressed in breast cancer (Slamon et al., 1984), has roles in tamoxifen resistance A current view of tamoxifen for the .. A high-efficiency HeLa cell
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nonhormone-dependent cervical cancer cells, HeLa in vitro. . Tamoxifen has been shown to have cytotoxic activity . Different Cell Lines in Vitro (MSc thesis).
nafoxidin and tamoxifen, but not 17β-estradiol inhibited PCB-induced Taken together, this thesis demonstrates that 15-LO-1 and cPLA2-α share several cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa
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Items 84 - 103 of 227 Browsing Theses - Biological Engineering by Title
Selective estrogen receptor modulators (SERMs), such as tamoxifen and raloxifene can act breast, Ishikawa endometrial, HeLa cervical and WAR-5 prostate cancer cells. .. thesis and purification, the biotin-labeled samples were evaluated
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A thesis submitted to the Faculty ofGraduate Studies and Research in partial fulfillment of the In butyrate resistant variants isolated from HeLa ceUs, clones 5.1 and 7.5 express high levels of Tamoxifen induces p21. Wafl and p27. Kipi
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By reading and using the thesis, the reader understands and agrees to the Tamoxifen is a synthetic anti-estrogen for post-menopausal women with and ALA-PDT induced JNK and p38MAPK activation in HeLa cells and human skin
Senior Thesis Titles Regulation of Estrogen Receptor Alpha (ERa) Mediated Transcription in HeLa Cells by an AFP 8-mer peptide. The Effect of AFP 8-mer Peptide/Tamoxifen Combination Therapy on Estrogen Receptor Activity in MCF-7
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used without apparent benefit to the patient were tamoxifen. (I.C.I. 46474 tamoxifen and fluoxymesterone. From this . tracts from HeLa cells were used as a reference line. Hormone .. thesis of a-lactalbumin is not a sine qua non criterion of
The research work described in thesis was performed under the signalling is associated with tamoxifen resistance in ER-positive breast cancer cells (Fox
copyright in this thesis. .. cancer spawned the idea that tamoxifen may be a potential hast cancer . Conversely. in ER-a negat ive HeLa (human cervical
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also decreased mitotic index, HeLa cells expressing. DRaf-1:ER were released from a thymidine-induced. G1/S block prior to addition of tamoxifen. The results
Analysis of liver RNA revealed that estrogen and tamoxifen exerts their plasma apo(a) .. These studies have consistently demonstrated that treatment with . of the IL-6 gene expression in HeLa and murine bone marrow cells by estrogen is
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Aims of the thesis. 27 adjuvant tamoxifen treatment-offer more? BCS . mastektomi, dvs hela bröstet opereras bort, men vanligare är bröstbevarande kirurgi.
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This thesis is based on the following papers, which are referred to in the text by their . Ex vivo studies of tamoxifen-induced adduct formation and cell stress in Jag vill också tacka min familj, farmor, kusiner… hela bunten, för allt roligt
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Specifically, two model reactive intermediates of the cancer drug tamoxifen, 1.8 Aim of Ph. D. project The aim of the work described in this thesis was to Mutagenic replication in human HeLa cell extracts, however, shows that the major
The effects of oral administration of tamoxifen at doses of 40 and 200 Thus, this study supports our thesis of tamoxifen as a potential male contraceptive agent.
Education, Blankfein, Frederick B, A Master's Thesis Production of a Play by Its Relationship to Estrogen and Tamoxifen, 1994, Located in Humanites 201 Science, Iorsh, Michael, Gemcitabine-Mediated Cytotoxicity in HeLa Cells, 1998
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Thesis submitted for the Degree of Doctor of Philosophy that adjuvant tamoxifen therapy significantly reduces the recurrence and mortality rates .. osteosarcoma), HeLa (human cervical cancer), COS-7 (monkey kidney) and CHO (hamster
Development and application of a stable HeLa cell line capable of site-specific transgenesis using the Cre-lox system: establishment and application of a stable
The content of this thesis has not previously been submitted for a degree HeLa human cervical tumour cell line. HEPES. 4-(2-Hydroxyethyl)piperazine conjugates to existing antitumour compounds: tamoxifen,129 Pt(II)
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Transfection of Hela cells with the two constructs resulted in expression of two HA profiles with hormone receptor status and response to tamoxifen. Cancer
Something that would reflect my thoughts about finishing my PhD thesis, something of activate ICl,swell in HeLa cells113, 114, HTC cells114 and rabbit ventricular myocytes115. tamoxifen both potently inhibited ELA cell proliferation.
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Thesis submitted in fulfillment of the requirements for the degree of. “Doctor in In the Tat transfer assay on HeLa P4.2 cells, the presence of Tat producing HIV female rat brain estrogen receptors by 17[beta]-estradiol and tamoxifen.
Thesis submitted in fulfillment of the requirements for the .. tamoxifen and transgenic mice that specifically overexpress constitutively active FoxO1 in of HeLa cell initiation factor 4F suggest a role in translational control.
Next, we studied the in vivo situation, by stimulating hela cells with In this thesis we have identified tamoxifen treatment predictive factors in premenopausal
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Tamoxifen remains a widely used hormone therapy for pre and post- .. I hereby declare that the work presented within this thesis is my own, unless transfected HeLa cells, oestrogen induces and tamoxifen inhibits ERα induced
Mitotic responses to irradiation of these control cell populations were not affected by treatment with tamoxifen and were identical to these of HeLa-PKB-ER cells
The work in this thesis was performed in the Department of Bioinformatics, such as that seen in breast cancer patients treated with Tamoxifen [30]. colon cancer cell lines, but are absent from metastatic colon cancer and Hela cell lines.
receptor action and their relevance to breast cancer drugs like tamoxifen. Over the .. The ER- negative HeLa cell line was also used for these experiments, but an expression thesis of fulvestrant is lengthy and difficult to modify in order to
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Selective estrogen receptor modulators (SERMs), such as tamoxifen and raloxifene Ishikawa endometrial, HeLa cervical and WAR-5 prostate cancer cells. Theses studies suggest amplification of the MT1 gene in some breast tumors and
for tamoxifen-inducible 'self-inactivating' insertional mutagenesis Beauty is active in some cell lines such as 293T and HeLa cells, it appears to be weakly
with hormone receptor status and response to tamoxifen. Cancer Res 2004;64( 11):3807-. 13. HeLa and MCF-7 mRNAs were used as positive and negative
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A thesis submitted to the Faculty of Graduate Studies and Research in partial fulfillment of the . 3.3 Results. 158. 3.3.1 Body weight and food intake during tamoxifen treatment HeLa whole cell lysate (50 μg, Santa Cruz Biotech.) was used
thesis from B.P. Koirala Institute of Health Sciences, Dharan, Nepal. Bandopadhyaya formulations of alginate-tamoxifen beads. G.P. 40 Singh M, Singh N. Induction of apoptosis in cervical cancer HeLa cells by curcumin, involvement
and HeLa cells (Milne et al., 2002; Nakamura et al., 2002). More- over, WT Mll tamoxifen (4-OHT) to induce Cre activity (Figure 1A, lane 2).
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Adjuvant tamoxifen treatment increases recurrence-free survival (RFS) and overall survival This thesis looks at impact analysis from a requirements engineering Läs hela. 6. Jönsson, Per, et al. (författare); Impact Analysis; 2005; Ingår i:
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“Outstanding Senior Honor's Thesis” award for his independent research .. the mitogenic action of estrogens in estrogen-dependent cancers (e.g., Tamoxifen,
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All of the work in this thesis was performed by Colin Stringer, with the such as ecdysone, cumate, tamoxifen, and tetracycline. HeLa cells are a human
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Original research report. Result of a thesis. i.e. IC50s were 35 µM and 55 µM for MCF-7 and Hela cells, respectively. The cytotoxic activity could be in part due
Conclusions: 1) These studies lend support to the thesis that long-term and cytotoxicity assay was done in Vero and Hela cells against Chandipura, Polio on reaching target tissues, we studied tissue penetration of tamoxifen (T) and its
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This thesis has been prepared from June 2006 to September 2009 in the laboratory of was tethered to the nuclear lamina by transfecting HeLa cells with an tamoxifen and followed with a GFP-labeled receptor and high resolution
By reading and using the thesis, the reader understands and agrees to the following terms: 1. The reader luciferase activities by ginsenoside Rgl in HeLa cells . . Figure 3- 5 Effect of ICI 182, 780 and tamoxifen on the regulation of IGF-IR
This thesis is dedicated to my parents, Kudsiya and Hassan… for all the using melatonin with tamoxifen in treating patients with metastatic solid .. osteosarcoma MG63 and cervical cancer HeLa cells and conclude that melatonin has no
of tumour cells. In adenocarcinoma cells (HeLa), zinc supplementation (100 umol /L) .. This thesis project studied the effect of zinc on the efficacy of tamoxifen in
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Results 251 - 300 of 1551 In this thesis we studied the effects of cigarette smoke (CS) on ATP depletion as a consequence of hypoxia enhances tamoxifen antiproliferative . In galactose medium, HeLa cells with mitochondria-targeted AOX
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The members of the Committee approve the thesis of Nadine Tassabehji defended on Enhancement of proliferation of HeLa cells by the alpha- .. Tamoxifen inhibits the growth of head and neck cancer cells and sensitizes these cells to
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bagin but not tamoxifen in BG-1 ovarian cancer cells. Mol Carcinog . induce growth arrest and apoptosis in HeLa cells and to inhibit cell motility in MCF7 cells [8] Pintão,A.M, Ph.D. Thesis, (to be presented) FCL, Lisboa.
In a study completed by Russo and co-workers, COS 7, HeLa and insulin-like growth factor 1 and tamoxifen, contain an AP1 binding
Title of PhD thesis: “Quantitative analysis of the estrogen receptor ß mRNA . Novel findings in clinical samples were confirmed by functional study in HeLa cells. receptor isoforms in breast cancer: possible role in tamoxifen resistance The
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SUMMARY OF DOCTORAL THESIS REFERENCE TO GROWTH REGULATION BY TAMOXIFEN lines derived from cervical (CasKi, HeLa, ME- 180)
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In a study similar to the aspirations of this thesis, mammalian mitochondrial NADH footprinting of HeLa cel mitochondrial DNA in relationship to ATP and . carcinoma cells in culture and effects of tamoxifen on exponentially growing and
Apoptogenic effects of ZER on HeLa were studied using fluorescence microscopy. (AO/PI double of Zerumbone on DES induced Cervical Cancer, M.S. thesis,. Universiti Putra . tamoxifen on two non-breast cancer cell types,” Journal of
The research described in this thesis was conducted in the Department of Gynaecologic. Oncology, University been shown to be predictive of responsiveness to tamoxifen therapy (24). CaSki and. HPV18-positive HeLa cell lines.
A Thesis Submitted to the College of Graduate Studies and Research in Partial mechanism by showing that HELA, CHO, and cervical neurons treated .. Tamoxifen works by increasing intracellular ceramide levels and
NRU)(Tani et al., 1999); the MTT test with HeLa cells (MTT-HeLa)(Chiba et al., 1999); The EC50 values of tamoxifen, toremifene, and chloroquine in 24-hour
thesis nor substantial extracts fkom it In butyrate resistant variants isolated fiom HeLa cells, ciones 5.1 and 7.5 express high Tamoxifen induces p21 W."
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The main goal of this thesis was to identify putative markers for prediction of clinical tamoxifen, as well as one with an impact on clinical outcome. Läs hela
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Thesis Submitted to the Faculty of the Virginia Polytechnic Institute and Current treatments, such as tamoxifen, are not consistently useful due to steroid hormone-regulated genes was shown using T-47D, HeLa, and
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HT-29 (human colon cancer) and HeLa (human cervical cancer) . Thesis. Universiti Putra Malaysia, Selangor, Malaysia. Pettit GR, Zhang Q,
thesis have identified epidermal IR/IGF-1R as key regulators of epidermal 2.14 IGF and insulin stimulation is not sufficient to re-activate HeLa cells .. expressing the tamoxifen-inducible K14Cre promotor as well as homozygous IGF -1R
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Thesis summarizing my work at UNC Chapel Hill on vascular of ROCK attenuates FAK phosphorylation in migrating HeLa cells105, and .. of FAK and enhances cellular migration in tamoxifen-resistant breast cancer cells.
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Guido Sauter for giving me the opportunity to perform my thesis in his had received adjuvant tamoxifen monotherapy, survival in women with ESR1 amplified HELA. CCL-2 cervix. B-C PAP thyroid carcinoma. 786-O. CRL-1932 kidney
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Publish your thesis, dissertation, term paper or essay. FIGURE 26-β- galactosidase staining of skin sections following Tamoxifen treatment .. For example, Jackson and Tjian showed that glycosylated Sp1 purified from HeLa cells was more
tamoxifen, which under conditions that isolate anion currents is a specific inhibitor of dependent activation of ICl,swell in HeLa cells (Shimizu et al., 2004).
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SwePub titelinformation: Effects of sex steroids and tamoxifen on VEGF in the breast [Elektronisk resurs] Läs hela texten (fulltext) In this thesis we have investigated the effects of estradiol, progesterone, and the nonsteroidal anti- estrogen
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In heterologous transfection studies in HeLa cells, TAM acted as an .. These data are consistent with the lower ER-agonist activity of RAL (29).
More recently, Miller et al. demonstrated that in HeLa cells ER α weakly . promoter activity in CHO cells treated with E2 and tamoxifen.
Therefore the aims of this Thesis work have been to test an set-up an efficient be activated by Tamoxifen (Hayashi and McMahon 2002) under the analysis nuclear protein extracts from MIN-6, small Maf factors from HeLa and a small
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The thesis of Preeti Ramadoss was reviewed and approved* by the following: Gary H. ligand binding in HeLa cells (50). Thus, XAP2 6-MCDF in combination with the ER antagonist Tamoxifen can also inhibit tumor formation in the
Tamoxifen abolished the effects of both estradiol and androgens on .. These results were confirmed by real-time PCR: TERT mRNA levels were .. as TERT promoter constructs transfected into HeLa cells were not activated.
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Records 1 - 20 This thesis describes the use of real time RT-PCR to compare PMCA in vitro cytotoxic activity on three cell lines, HepG2, MCF7, and HeLa.
The research project described in this thesis was performed within the framework of the research school oxidative metabolism of Tamoxifen. 47th ASMS .. CT from human cloned 5-HT1A receptors expressed in HeLa-cells. The affinity for
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in this thesis) were examined exclusively dealing with plants utilised in a clearly .. various tumours to be in fact derivatives of the well established HeLa cervical
estrogen and hydroxytamoxifen. Mol. Endocrinol. 7(2): 232-240. .. tamoxifen- mediated activation. Genesis. 38(3): tumorigenesis of HeLa cells. J. Exp. Clin.
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Detta beror på att användandet av datorer och andra enheter som använder sig av operativsystem ökar hela. .. Thesis (doctoral)--University of Göteborg, 1985. . Wnt-5a signaling restores tamoxifen sensitivity in estrogen receptor-negative
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A THESIS. SUBMITTED TO THE FACULTY OF GRADUATE STUDIES .. HeLa… …………………………………….. human cervical carcinoma cell line hormone antagonists, such as tamoxifen, are a cell-cycle non-specific group of drugs
This thesis is based on following original publications, which are referred to in text by tamoxifen inducible c-Myc (MycER) showed increased cell proliferation and self- Oncogenes in HeLa Cervical Carcinoma Cells Causes the Orderly
The first specific aim of this thesis was to develop a synthetic lethal adenocarcinoma MDA-MB-231, and cervical cancer Hela cells (Figure 27). activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in
The cancer cells, now called HeLa cells, grew rapidly in cell culture and We describe the history behind the development of HeLa cells, including the first
Tamoxifen can increase the disease-free survival and overall survival in on Induction of Apoptosis of Cervical Cancer Hela Cells and Clinical
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THE ROLE OF MICRORNAS IN MAMMARY TUMORIGENESIS. A Thesis estrogen receptor modulators (SERMs) such as Tamoxifen, which acts to inhibit . profiles, such as mir-17 to mir-20 in HeLa cells (Lagos-Quintana et al., 2001).
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A thesis submitted to fulfill the requirements for the degree of. Doctor of .. the group taking tamoxifen for 5 years than those on tamoxifen for 2 years. This result is has been described in HeLa St cells (Fanger et a1.,1984). No response
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Overexpression of AKT is associated with tamoxifen resistance in .. These experiments were performed on at least on three independent occasions. Studies have shown that well-characterized ER-negative HeLa cells
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This thesis is submitted to the University of Glasgow in accordance with the Using BTHS patients-derived lymphoblastoid cells and HeLa cells in which Modulators of steroid/retinoid family of nuclear receptors, such as tamoxifen, have
On having consulted this thesis you're accepting the following use .. with Oregon Green binds in a non-saturable manner to the cell surface in the HeLa such as vincristine (Rybak et al., 1996), tamoxifen (Lee et al., 2003), cisplatin ( Mikulski
thesis nor substantial extracts fiom it In embryonic stem cells expressing this fusion protein, tamoxifen was .. HeLa cells stably expressing tTA have been
I, Hilary Kathleen Siddall, confirm that the work presented in this thesis is my own. Where information has been in HeLa cells can cause an increase in apoptosis stimulated by TNFα. Furthermore, the Effects of tamoxifen on myocardial
Studies on BB-88 murine erythroleukemic and HeLa (human cervical cancer) cell lines have shown that tamoxifen inhibits cell multiplication with a drastic effect
Construction of HeLa cervical carcinoma cells stably expressing flag tagged This work will be submitted, in partial requirement of the PhD Thesis,
During hormone depletion or tamoxifen treatment of breast cancer cells the estrogen receptor .. In a murine HeLa cell tumor xenograft model, dexamethasone treatment increased both . Thesis (Ph. D.)--Medical College of Ohio, 1999.
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METHODS: Volume activated chloride currents were recorded from single HeLa cells using whole cell patch clamp technique. The ability of tamoxifen and its
Thus, the first aim of my thesis project was to engineer a new, fast and non invasive . estimated by HeLa cell transduction, and ranged from 5×107 to 108
Article (2) · Doctoral thesis (1) INTRODUCTION: Tamoxifen is effective for endocrine treatment of oestrogen Introduction of this gene into HeLa cells by DNA-mediated transfer results in the expression of Thy-1 antigen on the cell surface.
NAT2 Activity in HeLa Cell Cytosol. HeLa cell cytosol was prepared as described in Part III of this thesis. Cell cytosol (80 μL) and SMZ, dissolved in 10
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by cotransfecting HeLa cells with different pSuper-PP siRNA constructs .. recombinase in a time-specific manner, using tamoxifen administration in PP-
Apoptogenic effects of ZER on HeLa were studied using fluorescence microscopy M.S. thesis, Universiti Putra Malaysia, Kuala Lumpur, Malaysia, 2007. . “In vitro investigations on the toxicity and cell death induced by tamoxifen on two
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(SERMs), including Tamoxifen and ICI 182780, are compounds that are I certify that this thesis which I now submit for examination for the award of MPhil, hormone treated HeLa cells transfected with ERα:Dam and WT ERα.123
Tamoxifen (TAM) is an estrogen receptor antagonist used in the treatment of This thesis is dedicated to my Ioved parents who are the support of my spirit and source of Volume-Activated Chloride Currents in HeLa Ceiis are Blocked by
Using this approach we identified 669 ubiquitinated proteins from HeLa cells, including 44 precise ubiquitin attachment sites on substrates and all seven
In addition, luciferase reporter gene assay in HeLa cells transfected with ER PS, polystyrene; SD, styrene dimer; ST, styrene trimer; Tam, tamoxifen. 1. . compounds Vitamin D3 0.19 Naphthalene 100 a These compounds
Tamoxifen and 5-fluorourasil were very toxic to mononuclear perifer normal cell and vero cell line. The ethanol extract of highest toxicity to HeLa cell line derived from cervix carcinoma. .. Cell Lline, thesis, FMIPA UGM, 2005. 9. Denmeade
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In this thesis, we develop an approach to measure, analyze, and predict how complex amounts of HT-29 or HeLa lysates treated with known activators of the pathway of interest (for details, breast cancer patients treated with tamoxifen.
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